Calcium dependence of quantal secretion from visualized sympathetic nerve varicosities on the mouse vas deferens.
نویسندگان
چکیده
منابع مشابه
Morphological studies of stimulated adrenergic axon varicosities in the mouse vas deferens
The postganglionic axons of sympathetic neurons innervating the mouse vas deferens were stimulated transmurally in vitro by passing square pulses between two platinum electrodes. The ultrastructural appearance of the adrenergic nerve terminals was compared to samples fixed immediately after 30 min of stimulation and in samples allowed to recover for 2 h before fixation. The contralateral vasa d...
متن کاملIndividual sympathetic varicosities possess different sensitivities to alpha 2 and P2 receptor agonists and antagonists in mouse vas deferens.
1. The diversity of alpha(2) and purinergic autoreceptor actions on action potential evoked calcium transients in single varicosities has been investigated using the calcium indicator Oregon Green 488 BAPTA-1. 2. During long trains of impulses (10 Hz for 30 s), the change in calcium concentration in varicosities from its resting level (Delta[Ca(2+)](v)) increased in many varicosities during the...
متن کاملMechanisms Involved in Nicotinic Acetylcholine Receptor-Induced Neurotransmitter Release from Sympathetic Nerve Terminals in the Mouse Vas Deferens
Prejunctional nicotinic acetylcholine receptors (nAChRs) amplify postganglionic sympathetic neurotransmission, and there are indications that intraterminal Ca(2+) stores might be involved. However, the mechanisms by which nAChR activation stimulates neurotransmitter release at such junctions is unknown. Rapid local delivery (picospritzing) of the nAChR agonist epibatidine was combined with intr...
متن کاملSpinal cord segments controlling the canine vas deferens and differentiation of the primate sympathetic pathways to the vas deferens.
This study was undertaken to explore the spinal cord segments controlling the canine and human vas deferens and differentiation of the mammalian sympathetic pathways to the vas deferens. Thoracolumbar white communicating rami (WCR) were electrically stimulated in the dogs. Stimulation of the 1st, 2nd, 3rd, and 4th lumbar WCR elicited an elevation of intraluminal pressure of the vas deferens in ...
متن کاملVas deferens--a model used to establish sympathetic cotransmission.
The vas deferens has been used as a model for many diverse studies of different aspects of autonomic neurotransmission since its introduction including, in particular, sympathetic cotransmission involving release of ATP and neuropeptide Y together with noradrenaline and prejunctional and postjunctional neuromodulation. It has also been used to study sympathetic reinnervation following vasectomy...
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ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 1994
ISSN: 0022-3751
DOI: 10.1113/jphysiol.1994.sp020340